EVALUATION OF LATER MORPHOLOGIC ALTERATIONS IN RENAL ARTERY WALL AND RENAL NERVES IN RESPONSE TO CATHETER-BASED RENAL DENERVATION IN SHEEP: COMPARISON OF THE SINGLE-POINT AND MULTIPLE-POINT ABLATION CATHETERS.
Tématický okruh: Hypertenze, ateroskleróza | |
| Typ: Ústní sdělení - lékařské , Číslo v programu: 694 | |
Etický kodex: Konzultant: Bayer, Boehringer-Ingelheim, Amgen, Sanofi, MSDPřednášková činnost: Bayer, Boehringer-Ingelheim, Amgen, Sanofi, MSD Člen poradních sborů (advisory boards): Bayer, Boehringer-Ingelheim, Amgen, Sanofi, MSD Jiné honoráře (např. za klinické studie či registry): Klinické studie: Biotronik, Bayer | |
| Richter D.1, Táborský M.2, Kopkan L.3, Červenka L.3, Mrázová I.3, Herman A.4 1 I. interní- kardiologická klinika, Fakultní nemocnice Olomouc, Olomouc, 2 I. interní klinika, FN Olomouc, Olomouc, 3 Centrum experimentální medicíny, IKEM, Praha, 4 Klinika kardiologie, IKEM, Praha | |
This study evaluated the later subacute morphologic alterations in renal artery wall and renal nerves in response to catheter-based renal denervation in sheep and also compared the efficiency of the single-point and multiple-point ablation catheters. In 12 sheep, the effect of each ablation catheter approved for the clinical use (Symplicity FlexTM, Medtronic, INC. or EnligHTNTM, St. Jude Medical, INC.) was compared to intact contralateral renal artery by histopathology and immunohistochemistry evaluation after 10 days period post RDN procedure. The scoring system reflected either severity (or grade) of the damage to the artery wall and adjacent nerves, and the relative extent of these changes after 10 days post-RDN procedure. These values were calculated for each sample under study and presented as a The safety was verified by the extensive evaluation of the kidney morphology. The lesions of vascular wall and nerve injuries were more pronounced in the animals treated with multi-point EnligHTN catheter when compared with animals treated with single-point Symplicity Flex catheter. However; neither RDN procedure led to complete renal nerve ablation. Both systems tested in the present study provided only incomplete renal nerve ablation in sheep. Moreover, no appreciable progression of the nerve disintegration in subacute phase post-RDN procedure was observed (Figure1). This study further supports the notion that the effectiveness remains fully dependent on anatomical inter-individual variability of the sympathetic nerve plexus accompanying the renal artery. Therefore new systems that provide deeper penetrance to targeted perivascular structure would be more efficient. | |
