ATHEROGENIC INDEX OF PLASMA AS A DETERMINANT OF OXIDIZED LDL IN SLOVAK NON-CHD SUBJECTS

Identification of persons with increased oxidized LDL(oxLDL)can improve risk assessment of patients. Atherogenic Index of Plasma(AIP) a logarithmically transformed ratio of molar concentrations of triglycerides(TG)to HDL-C, reflects distribution of particle sizes in lipoprotein subclasses(HDL-C, LDL, VLDL). AIP increases with increasing cardiovascular risk and can be easily calculated from standard lipid profile.We therefore evaluated utility of AIP in clinical practice as a determinant of oxLDL levels.
Methods:We have examined 95 non-CHD subjects(18-75years old)involved in a cross-sectional Homocystein Slovakia study.Fasting levels of lipids and oxLDL were measured using standard methods. AIP was calculated as a log(TG/HDL-C) in molar concentration.Pearson’s correlation and linear regression analysis adjusted to age and sex were used to analyze the data.
Results:Main characteristics of subjects is in the table. AIP strongly positively correlated with oxLDL, LDL and apoB(r=0.44, 0.42,and 0.59,respectively, p<0.0001 for all) and negatively with apo AI(r= -0.45, p<0.0001).In simple regression analysis models using age and sex as covariates all AIP, apo-B (p<0.001 both), LDL and apo-AI(p<0.005 both)were significant determinants of oxLDL. However, when AIP was added to a models with LDL, apo-B and apo-AI, significance for the lipoproteins disappeared and AIP was the sole significant determinant of oxLDL.
Conclusions:AIP seems to be suitable determinant of oxLDL in Slovak non-CHD subjects,superior to LDL, apo-B and apo-AI. Simple measurements of Tg and HDL-C, expressed as a logarithmically transformed ratio,thus might help in evaluation of oxLDL status in everyday clinical practice.