VALIDATION OF THE CARDIOMETABOLIC-BASED CHRONIC DISEASE (CMBCD) MODEL IN U.S. ADULTS.

Background: The Cardiometabolic-Based Chronic Disease (CMBCD) model is a four-stage driver and complication-based chronic approach. It was designed as an actionable strategy, advocating for earlier intervention
Aim: To validate the CMBCD model by examining risk for CVD and all-cause mortality
Methods: Data from the National Health and Nutrition Examination Surveys (NHANES) of the US (1999-2012) was linked to mortality files until 2015. Adults aged 40-74 years were analyzed. The CMBCD model is divided into 4 stages: 1-risk, 2–predisease, 3–disease, and 4–complications. Kaplan-Meier survival curve estimates and Cox regression models were calculated.
Results: 7261 subjects were included, mean age of 53.5 ± 0.18 years, followed by 8.1 years. There were 160 CVD and 811 all-cause deathly cases. The cumulative rates for CVD and all-cause mortalities rates were 2.5 and 12.9 per 1000 person-years, respectively. The cumulative CVD-mortality rates for each CMBCD stage were without risk/stage 1, 0.8; stage 2, 1.1; stage 3, 1.7; and stage 4, 6.3, per 1000 person-years (pConclusion: Subjects with complications presented a higher risk of mortality than those without it. These results highlight the relevance of early detection and intervention using a complication-based chronic approach.