CIRCADIAN RHYTM OF HEART RATE TURBULENCE IN HEALTHY SUBJECTS

Objective: To detect the parameters of circadian rhytmicity of heart rate turbulence (HRT) in a group of patients without organic heart disease.
Methods: We selected the group healthy patients with 24hour Holter recordings. For each patient were calculated : the total HRT (included the parameters turbulence onset-TO and turbulence slope- TS), the number of VPBs (ventricular premature beats) and HRT after two and four hours.
Results: HRT was determine for 48 patients (23 men,25 women),the average age was 48,4 years (+-15,3). The results after 2 hours: the quantity of VPBs and TO -with no significant different (p=0,917, p=0,253). There was found significant different in parametr TS
(p< 0,001). The results after 4 hours:the different of TS (p=0,001), the other parameters no significant (numebr of VPBs with p=0,609, TO with p=0,133).
Conclusions: The parameter TS shows significant variability during the day. In nighty hours the values of TS are higher.The parametr TO manifests the certain variability (like the trend of TS), but it is not important variability. The demonstrability of daily variability of HRT is present in the evalution after 2hours,but this demonstrability after 4hours disappears and confirms the absence of  evident distinct trend. As optimal time for detection of HRT is the interval between 10 and 12 o´ clock AM.

In support of the grant :NR/8478-3.