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ACUTE SEVERE HEART FAILURE IMMEDIATELY REDUCES HEART RATE VARIABILITY: AN EXPERIMENTAL STUDY IN PORCINE MODEL.

J. Naar, M. Mlček, A. Krüger, D. Vondráková, M. Janotka, M. Popková, O. Kittnar, P. Neužil, P. Ošťádal (Praha, Praha 5)
Tématický okruh: Obecný okruh
Typ: Ústní sdělení - lékařské, CCRID 2022

Background: There are substantial differences in autonomic nervous system activation among heart failure (HF) patients and immediate effect of acute HF on autonomic function is not fully understood.
Objective: The aim our study was to assess the effect of experimental acute HF on heart rate variability (HRV).
Materials and methods: Twenty-four female swine of mean body weight 45 kg were used. Acute severe HF was induced by global myocardial hypoxia. In each subject, two 5-minute electrocardiogram segments were analyzed and compared: before the induction of myocardial hypoxia and > 60 min after the development of severe HF. HRV was assessed by time-domain, frequency-domain and nonlinear analytic methods.
Results: Induction of acute HF led to significant decrease in cardiac output, left ventricular ejection fraction and rise in heart rate. Development of acute HF was associated with a significant reduction of standard deviation of intervals between normal beats (50.8 [20.5 – 88.1] ms vs. 5.9 [2.4 – 11.7] ms, p < 0.0001) - figure 1. Highly significant a uniform reduction of HRV was observed also in other time-domain and main nonlinear analytic methods. Similarly, frequency-domain HRV parameters were significantly changed.
Conclusion: Acute severe HF induces an immediate reduction in HRV.